Abstract
Prostaglandin F 2α consistently produced a dose-related triphasic response in guinea-pig isolated tracheal chain preprations. The response consisted of an initial transient contraction followed by a transient relaxation, followed by a further contraction. The relaxant action was not due to adrenergic or histaminergic transmission, but might be due to a PG-like material released by the PGF 2α-induced contraction.
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