Abstract

The course of reinnervation of a skeletal muscle, whose own myoneural apparatus has been damaged by botulinus toxin, by an implanted nerve was investigated in experiments on rats in order to determine the essential conditions for regeneration of nerve fibers in an area of paralysis due to botulism. Injection of a sublethal dose of the toxin into the limb was shown to hasten synaptogenesis of the implanted nerve. As a result, restoration of the normal weight of muscle tissue and the level of polarization of its fibers was promoted.

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