Abstract
The present state of our knowledge of the OH radical-induced strand break (sb) formation in presence and absence of oxygen in aqueous solution is reviewed for poly(U), poly(C), poly(A) and single- and double-stranded DNA as substrates. It was shown earlier that a single OH radical can induce a double-strand break in DNA. As a key step in the mechanism an interstrand radical transfer is postulated. The OH radical reaction is part of the indirect effect of γ-irradiation. In addition recent results are presented concerning sb formation by the direct effect of high-energy irradiation using laser-induced photoionization for the formation of radical cations.
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