Mechanism of phosphatidylserine inhibition of IgE/FcεRI-dependent anaphylactic human basophil degranulation via CD300a

Abstract

The process that leads to histamine release from human basophils constitutes a continuum that starts with piecemeal degranulation and eventually converts to anaphylactic degranulation (AND).1,2 These degranulation events are accompanied by mobilization of distinct cellular compartments and expression of surface molecules that are not or barely expressed on resting basophils. Two different histamine-containing compartments, which show distinct early signaling requirements and kinetics, have been described, namely, the CD203c compartment and the CD63 compartment.