Abstract
The kinetics of oxidation of diazepam (DZ) by 1-chlorobenzotriazole (CBT) has been studied in HClO4 medium in the temperature range of 293–323 K. The reactions followed a first order dependence on [CBT], fractional order each in [H+] and [DZ]. Activation parameters were evaluated. A negative entropy of activation indicated the involvement of a rigid complex in the activated state. Variation of reaction rate with dielectric constant and the ionic strength are consistent with a mechanism involving the decomposition of a dipole in the rate-determining step. Rate equation is derived to account for the observed kinetic data and the proposed reaction mechanism.
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