Mechanism of nonlinear responses of taste cells to mixed tastes.

Abstract

Coupling between ionic flows through different kinds of channels affects essentially the responses of multisensitive taste cells to single- and mixed-taste stimuli. The mechanism of taste transduction is studied by using a realistic model of the multisensitive cells of the rat. The transduction pathways considered are amiloride-sensitive Na+ channels for NaCl and HCl and adenosine 3',5'-cyclic monophosphate-mediating K+ channels for sucrose. Contributions of paracellular pathways and taste-insensitive ionic channels are also studied. The calculated responses of various multisensitive cells induced by single stimuli of NaCl, HCl, or sucrose reproduce experimentally observed responses as well. The two main conclusions are as follows. 1) Whether the response of a cell to a binary mixture becomes synergetic or antagonistic can be estimated from the individual responses of the cell to each component of the mixture. 2) Whether the response is enhanced or suppressed by addition of a new taste to the original taste can be determined, for most receptive cells, from a viewpoint of linear superposition of the individual responses.