Abstract
ANIMALS are aware of X-radiation1, but no one knows how they achieve this awareness. Recently, a biological tool, the acatalasaemic mouse developed in this laboratory2, has become available to test the one mechanism which has been seriously investigated. The acatalasaemic mouse is a mutant strain, CSb, which differs from its normal, wild type progenitor strain (CSa); the blood catalase activity of the mutant is about 1 per cent of normal. The catalase activity of the solid tissues is also reduced3, but it is difficult to measure the change because the mutation is more a modification of molecular stability than change of actual activity and thus is critically dependent on the method of assay used4.
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