Mechanism of Mitochondrial Damage in Cardiac Dysfunction Induced by Sepsis

Abstract

Sepsis is a syndrome with a high fatality rate, which is the dysfunction of multiple organs in the whole body caused by the host’s inflammation response caused by infection. The cardiac insufficiency caused by sepsis is called Septic-Induced Myocardial Dysfunction (SIMD), which is mainly characterized by bilateral systolic and diastolic dysfunction of the heart, which is one of the most serious complications of sepsis. Normal mitochondrial structure and function are essential for maintaining mitochondrial homeostasis. Mitochondrial homeostasis plays a central role in the pathophysiology of SIMD, and its structural changes, oxidative stress, inflammation, endoplasmic reticulum stress and autophagy are directly or indirectly related to the occurrence and development of SIMD, which has a promising future as a targeted therapy for SIMD. Therefore, this paper focuses on the molecular mechanism and signaling pathway of mitochondrial homeostasis in the pathogenesis of SIMD, and provides implications for the search for therapeutic targets and biomarkers of SIMD. In addition, many traditional Chinese medicine components play a protective role in maintaining mitochondrial homeostasis in sepsis, and have the potential to be developed as novel therapeutics for SIMD.