Abstract
Mechanism of Long Non-Coding RNAs in Autophagy and Inflammation of Vascular Endothelial Cells: A Review
Highlights
As a monolayer covering the vascular lumen, vascular endothelial cells could integrate into the vascular endothelium [1]
We have systematically reviewed the role and molecular mechanism of long non-coding RNAs (lncRNAs) related to endothelial cell autophagy and inflammation in human cardiovascular diseases
This locus is adjacent to the last exon of a lncRNA named antisense noncoding RNA in the INK4 locus (ANRIL), whereas the 2 other protein-coding genes lie >100 kb from associated single nucleotide polymorphisms (SNPs), suggesting that SNPs on ANRIL are more likely to contribute to the susceptibility of coronary artery disease [9]
Summary
As a monolayer covering the vascular lumen, vascular endothelial cells could integrate into the vascular endothelium [1]. The vascular endothelium equips with highly specialized structure and spreads around the whole body It possesses many essential properties, such as supplying blood and oxygen, transmitting nutrient, maintaining metabolic homeostasis as well as trafficking immune cells [2]. LncRNAs has been identified to exert crucial roles in many diseases via their diverse functional activities and specific mechanisms. Dysfunction of endothelial cells related to stimulation of inflammatory factors is implicated in the development of a variety of vascular diseases [1]. In the field of vascular biology, the current investigation of IncRNA in inflammation has focused on other cell types, such as macrophages [9], yet the role of lncRNA in mediating the inflammatory response of endothelial cells remains to be elucidated. We have systematically reviewed the role and molecular mechanism of lncRNAs related to endothelial cell autophagy and inflammation in human cardiovascular diseases
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