Abstract
Renal sodium excretion and solute free water clearance were examined during hypotonic saline diuresis in four patients with cirrhosis and ascites and in four normal subjects. (C H 2O + C Ma) C In was used as an index of fractional distal tubule sodium load and C H 2O C H 2O + C Na × 100 as the per cent of this load reabsorbed at the distal tubule. The results demonstrate that the distal sodium supply is similar in both groups and that fractional sodium reabsorption is enhanced at the water clearing segment of the nephron. On the basis of the present data we suggest that sodium retention in some cirrhotic patients, accumulating edema and ascites result from an increase in distal tubular fractional sodium reabsorption.
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