Abstract
A sequential mechanism for endothelium-dependent vasorelaxation is proposed. The following events appear to be involved: Endothelial cell : activation of a receptor → activation of membrane phospholipases → increase in intracellular free Ca 2+ → formation of endothelium-derived relaxing factor(s) (EDRF) via a cytochrome P 450 - dependent epoxygenase or non-enzymatic lipid peroxidation pathway → release of EDRF → diffusion of EDRF to the smooth muscle cell; Smooth muscle cell : activation of guanyl cyclase → activation of protein kinase → protein phosphorylation → dephosphorylation of myosin light chain → relaxation. Relationships between endothelium-dependent and endothelium-independent vasorelaxation are indicated. EDRF-candidates include aldehydes and epoxides.
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