Abstract
The following evidence has been presented as proof of the mutational origin of streptomycin resistant variants of five different species—E. coli, Salmonellae, Shigellae, S. typhosa and Ps. aeruginosa: 1. Demonstration of their independence of the action of streptomycin by showing their continuous irregular occurrence with different prevalence in independent cultures of same population size and strain. 2. Transmission of resistance unchanged in degree through many subcultures in the absence of streptomycin. 3. A low rate of occurrence of the resistant variants, not varying significantly among different strains of the same species. A fraction of the resistant mutants of each of these five organisms grows poorly or not at all in the absence of high concentrations of streptomycin. The therapeutic implications of these facts are discussed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
