Mechanism of Dihydromyricetin on Inflammatory Diseases.

Yang Sun,Xudong Zhou,Chen Chen,Chao Liu,Qidi Ai,Naihong Chen,Songwei Yang,Wei Wang,Wenmao Wang,Shasha Liu,Meiyu Lin,Yantao Yang

doi:10.3389/fphar.2021.794563

Abstract

Inflammation plays a crucial role in a variety of diseases, including diabetes, arthritis, asthma, Alzheimer’s disease (AD), acute cerebral stroke, cancer, hypertension, and myocardial ischemia. Therefore, we need to solve the problem urgently for the study of inflammation-related diseases. Dihydromyricetin (DHM) is a flavonoid mainly derived from Nekemias grossedentata (Hand.-Mazz.) J.Wen and Z.L.Nie (N.grossedentata). DHM possesses many pharmacological effects, including anti-inflammatory (NLRP-3, NF-κB, cytokines, and neuroinflammation), antioxidant, improving mitochondrial dysfunction, and regulating autophagy and so on. In this review, we consulted the studies in the recent 20 years and summarized the mechanism of DHM in inflammation-related diseases. In addition, we also introduced the source, chemical structure, chemical properties, and toxicity of DHM in this review. We aim to deepen our understanding of DHM on inflammation-related diseases, clarify the relevant molecular mechanisms, and find out the problems and solutions that need to be solved urgently. Providing new ideas for DHM drug research and development, as well as broaden the horizons of clinical treatment of inflammation-related diseases in this review. Moreover, the failure of clinical transformation of DHM poses a great challenge for DHM as an inflammation related disease.

Highlights

Dihydromyricetin (DHM) is a flavonoid mainly derived from Nekemias grossedentata (Hand.Mazz.) J.Wen and Z.L.Nie (N.grossedentata) (Liu et al, 2019a)
Numerous studies have shown that inflammation plays a vital role in a variety of diseases, including diabetes, arthritis, asthma (Zhong and Shi, 2019), Alzheimer’s disease (AD), acute cerebral stroke, cancer, hypertension, and myocardial ischemia (Liu et al, 2019a; Figure 4)
This review summarizes the mechanism of DHM in inflammatory diseases according to its different effects systematically, focusing on the research progress of DHM in anti-inflammatory, apoptosis, oxidative stress, and the effects of various metabolic pathways

Summary

Introduction

Dihydromyricetin (DHM) is a flavonoid mainly derived from Nekemias grossedentata (Hand.Mazz.) J.Wen and Z.L.Nie (N.grossedentata) (Liu et al, 2019a). Flavonoids have multifarious pharmacological effects, such as antioxidant, anti-inflammatory response, anti-cancer, and antiviral as well as neuroprotective effects (Wang et al, 2016a). DHM has numerous biological effects, including anti-oxidation, improving mitochondrial dysfunction, and regulating autophagy (Liu et al, 2020), Mechanism of Dihydromyricetin especially anti-inflammatory effects (Zhang et al, 2018). This suggests that DHM exerts its pharmacological effects through the corresponding molecular mechanisms

Objectives

Conclusion