Abstract
The cause of the decrease in number of antibody-producing cells formed on induction of the primary immune responsein vitro, observed when the surface density (the number of cells per square centimeter floor of the incubation vessel) was increased was studied. Depression of antibody formation in high-density cultures was found to be due, not to disturbance of induction of the clone of antibody-forming cells, but to inhibition of the subsequent proliferation of the cells of that clone. The disturbance of proliferation is reversible: A decrease in the density of the cultures 1 or 3 days after the beginning of incubation led to resumption of the increase in number of antibody producers. The depressant effect cannot be transferred humorally from high-density to low-density cultures. It cannot be abolished by changing the incubation medium of high-density cultures daily for fresh nutrient medium.
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