Abstract
Applying high-frequency stimulation to deep brain structures, known as deep brain stimulation (DBS), has now been recognized as an effective therapeutic option for patients with a wide range of neurological and psychiatric disorders. DBS targeting the basal ganglia-thalamo-cortical loop, especially the internal segment of the globus pallidus, subthalamic nucleus, and thalamus, has been widely employed as a successful surgical therapy for movement disorders, such as Parkinson’s disease, dystonia, and tremor. However, the exact mechanism underling the beneficial effects of DBS remains to be clarified and is still under debate: Does DBS inhibit or excite local neuronal elements? In this chapter, we will discuss the physiological mechanism of DBS and propose an alternative view: DBS dissociates input and output signals, resulting in the disruption of abnormal information flow through the stimulation site.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
