Mechanism of Baoyuan Decoction in the Treatment of Chronic Heart Failure Based on Network Pharmacology

Abstract

This study aims to explore the material basis and mechanism of Baoyuan decoction in the treatment of chronic heart failure by network pharmacology and molecular docking technology. There are 144 effective active ingredients and 253 targets in Baoyuan decoction. The key ingredients mainly include flavonoids such as quercetin, naringenin and glazin. There are 240 intersecting targets between Baoyuantang and chronic heart failure, and its core targets include jun proto-oncogene, signal transducer and activator of transcription 3, tumor protein 53, transcription factor p65, mitogen-activated protein kinase 14, estrogen receptor 1, etc. The gene ontology and kyoto encyclopedia of genes and genomes enrichment analysis results show that it mainly involves 2475 biological processes, 104 cell components, 253 molecular functions and 174 related signals pathway. It mainly regulates the evolutionary processes including nutritional response, inflammatory response, oxidative stress response, apoptosis signal pathway etc., through the cell components such as cytoplasm, cell membrane and synapse, and exerts the molecular functions of DNA binding transcription factor, RNA polymerase II specific DNA binding transcription factor, serine/ threonine kinase activity, ubiquitin-like protein ligase binding, through phosphatidylinositol 3 kinaseprotein kinase B, Mitogen-activated protein kinase 14, Advanced glycation end products-receptor for AGE, Interleukin-17, apoptosis, cancer and other signaling pathways to play a role in the treatment of chronic heart failure effect.