Abstract
Antibiotics are the natural, synthetic or semi synthetic compound .For decades it used as weapon in the battle against pathogens (bacteria, fungi, parasite, etc.) that attach the life of agriculture and animal husbandry. For that, the antimicrobial agents used in therapeutic and prophylactic purpose. Unfortunately, the microbes have become resistant to different antibiotics by development of their mechanism action. The lists of infectious diseases were grown due to increase of resistance at an alarming rate and the then antibiotics are less effective. High morbidity and mortality ratio come from wrong diagnosis of pathogen that lead to wrong treated by antibiotics because appeared new strains called multidrug-resistant bacteria .The aim of this review is to explore the Mechanism action and resistance style of antibiotics
 Keywords: β-lactam, Cephalosporins, Aminoglycosides, Macrolide, Quinolones
Highlights
High morbidity and mortality ratio come from wrong diagnosis of pathogen that lead to wrong treated by antibiotics because appeared new strains called multidrugresistant bacteria .The aim of this review is to explore the Mechanism action and resistance style of antibiotics Keywords: β-lactam, Cephalosporins, Aminoglycosides, Macrolide, Quinolones
The beta-lactum ring is found in the synthesis of these antibodies figure[1], and it has a role in preventing the cell wall of bacteria from synthesis through binding the antibiotic to special proteins within the cell membrane named penicillin Binding Proteins (PBPs).They inhibit the enzyme Transpeptidase, which forms peptide chains that bind to the peptidoglycan forming layers figure [2](Zervosen et al, 2012)
Semi-synthetic antibiotics, containing in their composition a beta-lactam ring linked to a dihydroziazine ring figure [3], and they have a broad spectrum activity against Gram-positive and other bacteria and are resistant to penicillin and are used as alternatives for patients who are allergic to penicillin (Hancu et al, 2013)
Summary
|| ISSN(online): 2589-8698 || ISSN(print): 2589-868X || International Journal of Medical and Biomedical Studies. Available Online at www.ijmbs.info PubMed (National Library of Medicine ID: 101738825). Index Copernicus Value 2018: 75.71 Volume 4, Issue 2; February: 2020; Page No 128-136. MECHANISM ACTION AND RESISTANCE STYLE OF ANTIBIOTICS Saba T. Fatima R.Abdul, Bahaa Abdullah Laftaah AL-Rubaii4 1،2,3Mustansiriyah University, College of Science, Biology Department, Baghdad, Iraq 4The University of Baghdad, College of Science, Biology Department, Baghdad, Iraq. Hashim Conflict of interest: No conflict of interest
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