Abstract
Mathematical and computational modeling of the stomach is an emerging field of biomechanics where several complex phenomena, such as gastric electrophysiology, fluid mechanics of the digesta, and solid mechanics of the gastric wall, need to be addressed. Developing a comprehensive multiphysics model of the stomach that allows studying the interactions between these phenomena remains one of the greatest challenges in biomechanics. A coupled multiphysics model of the human stomach would enable detailed in‐silico studies of the digestion of food in the stomach in health and disease. Moreover, it has the potential to open up unprecedented opportunities in numerous fields such as computer‐aided medicine and food design. This review article summarizes our current understanding of the mechanics of the human stomach and delineates the challenges in mathematical and computational modeling which remain to be addressed in this emerging area.
Highlights
Healthcare problems related to the stomach are among the most important causes of morbidity in industrialized countries
Substantial progress has been made in all these fields,[22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39] and rapid advances in computational power allow addressing even complex multiphysics problems nowadays. Benefitting from these recent advances, the time has come to tackle one of the still open big questions of biomechanics, which is the development of a comprehensive mathematical and computational multiphysics model of the stomach, which allows for detailed in-silico studies of the mechanics and mathematical principles governing the digestion of food in the stomach
They play a role in controlling gastric electrophysiology by transducing input signals from the enteric nervous system
Summary
Healthcare problems related to the stomach are among the most important causes of morbidity in industrialized countries. Substantial progress has been made in all these fields,[22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39] and rapid advances in computational power allow addressing even complex multiphysics problems nowadays Benefitting from these recent advances, the time has come to tackle one of the still open big questions of biomechanics, which is the development of a comprehensive mathematical and computational multiphysics model of the stomach, which allows for detailed in-silico studies of the mechanics and mathematical principles governing the digestion of food in the stomach. It may serve as a convenient starting point in particular for applied mathematicians and engineers who have interest to start research in this emerging area of biomechanics
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