Abstract
This study intends to investigate how the elasticity of a bacterial phage can affect the process of DNA packaging and ejection. For this purpose, we propose a unified continuum and statistical mechanics model by taking into account the effects of DNA bending deformation, electrostatic repulsion between DNA-DNA strands and elastic deformation of the phage capsid. Based on such a model, we derive the quantitative relations between packaging force, elasticity of capsid, DNA length remaining in the capsid, osmotic pressure and ejection time. The theoretically predicted results are found to agree very well with in vitro experimental observations in the literature.
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