Abstract
A general method was developed for promoting peptide assembly and protein polymerization to form nanoscale patterns on various surfaces with an atomic force microscope (AFM) operated in a liquid. By scanning solid surfaces with an AFM tip, we showed that peptide monomers assemble at a higher rate in the tip-scanned area compared to other regions. The promotion is attributed to the mechanical force applied by the scanning tip. This kind of mechanical-force-promoted assembly was also observed with different peptides on various substrates. The force promoting peptide assembly provides a simple and practical solution for preparing and building peptide and protein architectures for future nanodevices.
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