Abstract

Purpose: To evaluate the safety and efficacy of mechanical thrombectomy (MT) for acute stroke due to large vessel occlusion (LVO), presenting with mild symptoms.Methods: A prospective cohort study of patients with mild ischemic stroke and LVO was conducted. Patients were divided into two groups: MT group or best medical management (MM) group. Propensity score matching (PSM) was conducted to reduce the confounding bias between the groups. The primary outcome was functional independence at 90 days. The safety outcome was symptomatic intracranial hemorrhage (sICH). Univariate and multivariate logistic regression analyses were used to identify the independent factors associated with outcomes.Results: Among the 105 included patients, 43 were in the MT group and 62 in the MM group. Forty-three pairs of patients were generated after PSM. There were no significant differences in sICH rates between two groups (p = 1.000). The MT group had a higher proportion of independent outcomes (83.7% MT vs. 67.4% MM; OR 2.483; 95% CI 0.886–6.959; p = 0.079) and excellent outcomes (76.7% MT vs. 51.2% MM; OR 3.150; 95% CI 1.247–7.954; p = 0.013) compared to the MM group, especially in patients with stroke of the anterior circulation (p < 0.05). Multivariate logistic regression analysis showed that small infarct core volume (p = 0.015) and MT treatment (p = 0.013) were independently associated with excellent outcomes.Conclusions: Our results suggest that MT in stroke patients, presenting with mild symptoms, due to acute LVO in the anterior circulation may be associated with satisfactory clinical outcomes.Clinical Trial Registration: ClinicalTrials.gov, identifier: NCT04526756.

Highlights

  • Mechanical thrombectomy (MT) has been globally acknowledged as a standard treatment for patients with acute ischemic stroke patients (AIS) and large vessel occlusion (LVO)

  • Two patients were excluded because of a pre-stroke modified Rankin Scale (mRS) >2, one in the MT group was excluded for spontaneous recanalization, and two patients in the MM group were excluded for rescue MT due to neurological worsening

  • Of the two excluded patients, one was excluded because he had acute occlusion of the contralateral middle cerebral artery during hospitalization, which was not related to this stroke

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Summary

Introduction

Mechanical thrombectomy (MT) has been globally acknowledged as a standard treatment for patients with acute ischemic stroke patients (AIS) and large vessel occlusion (LVO). Patients with LVO presenting with a low NIHSS score were found to be a high risk of clinical worsening of the condition, leading to poor outcome [15]. It is still unclear whether patients with minor stroke and LVO can benefit from MT. Several studies have focused on this topic, but the results are inconsistent [16,17,18,19] The aim of this prospective study is to evaluate the relationship between MT and the clinical outcome of acute LVO with mild symptoms

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