Mechanical stimulation of cerebral organoids toward understanding human neural response

Abstract

The ability to model physiological processes within 3D brain in vitro systems may enable new treatments while lowering the need for challenging animal and human testing. Creating such an environment that mimics areas such as the nervous system under mechanical stimulation would be extremely useful to study a range of in vivo biological processes and conditions related to trauma. Such models, referred to as human cerebral organoids, have been shown to faithfully recapitulate key cytoarchitectural features of the human brain and represent another approach in the area of more traditional 2D cultures, organ-on-a-chip models, and in vivo models.