Mechanical restitution curves reflect post-ischemic stunning in pigs

Abstract

ObjectivesThe time constant of mechanical restitution (T(MRC)), proposed to reflect changes in calcium release and uptake, has been shown to increase in left ventriculariz (LV) failure. In this study, we tested the hypothesis that T(MRC) also can identify post-ischemic, reversible LV dysfunction (stunning).DesignStunning was induced by a series of left main coronary artery occlusions in eight anesthetized open chest pigs. Left ventricular pressure–volume relations were assessed using a pressure–volume catheter during right atrial pacing. Mechanical restitution curves (MRCs) were constructed using two different measures of contractile response: maximal first derivative of pressure (CR(dP/dtmax)) and stroke work (CR(SW)).ResultsMean arterial pressure, stroke volume and dP/dtmax were decreased 30 min after stunning. Slopes of end-systolic pressure volume relation and preload recruitable stroke work, however, showed no significant changes after stunning. For MRCs based on CR(dP/dtmax), T(MRC) increased in all eight animals. Using CR(SW), T(MRC) increased in seven out of eight pigs.ConclusionsIschemia–reperfusion induce changes in MRCs based on CR(dP/dtmax) and CR(SW). The MRC concept may have potential as a clinical left ventricular performance index.