Abstract
Recent advances in understanding of mechanical bone remodeling have been progressed by computational mechanics approach that allows analysis of structural and functional changes of bone with hierarchical structure under complicated mechanical environment. In this study, a simulation method of trabecular surface remodeling for cancellous bone was proposed using digital image-based finite element model in which mechanical environment at the trabecular level relating to cellular activities could be directly estimated. Morphological changes of trabeculae due to remodeling were simulated based on uniform stress hypothesis, that is, the resorption and formation were accomplished by removal and addition of the voxel elements on the trabecular surface driven by stress nonuniformity. Remodeling simulation of cancellous bone cube under compressive loading was conducted using a digital image-based model constructed based on μCT data from distal canine femur. Simulation results demonstrated that the changes in structural indices of cancellous bone qualitatively corresponded with experimental results, and the proposed simulation method has potential to predict the functional adaptation phenomena in cancellous bone.
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