Abstract
Uniform and well dispersed nano hydroxyapatite (HA)–gelatine composites were obtained by co-precipitation of hydroxyapatite and denatured calf skin collagen. The process allowed much higher concentration of hydroxyapatite to be produced over conventional hydrothermal process to improve the productivity. The effect of gelatine on the morphology, mechanical properties, and biocompatibility of hydroxyapatite particles was investigated. Fibroblast cell tests of the consolidated hydroxyapatite–gelatine composites showed that the composites have excellent biocompatibility.
Highlights
An extremely specialized supporting framework of the body protecting the vital organs is bone
The width of the plates is about 2 m and the thickness is about 80 nm according to Scanning electron microscopy (SEM) measurements
In order to explain this, various factors such as preparation time and aging period should be taken into consideration. This significant difference in the morphology of the crystals could arise as a result of the mixing rate of the precursor solutions as it has a direct impact on the nucleation of HA
Summary
An extremely specialized supporting framework of the body protecting the vital organs is bone. Natural bone is a composite material composed of hybrid organic and inorganic constituents. It has a varied arrangement of material structures at many length scales which work in concert to perform diverse mechanical, biological, and structural properties. The uninterrupted growth in the life expectancy of population has led to continuous conditions which are prone to injury causing severe damage to the individual. While bone is inherently capable of regeneration, complications such as excessive bone loss impede healing, necessitating the use of bone grafts [1]. Bone is one of the most frequently implanted tissues in human body, second only behind blood. Due to the advances in biomaterial research, it is possible to artificially fabricate
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