Abstract
Acid extracted collagen from rat skin was reconstituted into fibrils at physiological pH and ion concentration. The fibrils were indistinguishable from native collagen in ultrastructural appearance. This report describes a procedure for reconstituting collagen fibrils into thin membranes which allows the preparation of a set of collagen membranes with identical mechanical properties. Reconstituted collagen fibrils showed a gain in mechanical strength upon maturation in vitro similar to the increase in mechanical strength known to occur during maturation of collagenous tissues in vivo. It is suggested that the changes in the mechanical properties of reconstituted collagen fibrils during in vitro maturation may reflect the changes observed during in vivo maturation of collagenous tissues. The possible influence of the amounts of reducible intermolecular cross-links on the gain in strength during maturation is discussed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
