Abstract
The aim of this study was to prepare the pectin film-based different types of Eudragit® polymer blends using glycerine as a plasticizer and to study the mechanical properties of these films. The mixing of polymer mixture was carried out using distilled water as a solvent throughout the experiment. The polymer mixture was poured into Petri dish and transferred to hot air oven for solvent evaporation. The maximum positive force and percentage of elongation at break were found at the range of 63.58-409.94 g and 74.92-145.42%, respectively for pectin film-based Eudragit® RL 30D polymer blends, 87.12-409.94 g and 74.42-145.42%, respectively for pectin film-based Eudragit® RS 30D polymer blends, 76.50-409.94 g and 72.68-145.42%, respectively for pectin film-based Eudragit® NM 30D polymer blends, and 137.12-409.94 g and 44.42-145.42%, respectively for pectin film-based Eudragit® NE 40D polymer blends. The results indicated that the mechanical properties of the pectin film decreased with inclusion of various types of Eudragit® (p < 0.05). However, it was found that the pectin film-based different types of Eudragit® polymer blends has high potential to be used in pharmaceutical applications. Further investigation related to the incorporation of drugs or herbal extracts and the in vitro evaluation are recommended.
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