Abstract
α-Tropomyosin (αTm) is a 66kDa alpha-helical coiled-coil protein in thin filaments of cardiac muscle. Together with the Troponin complex (Tn), it is responsible for Ca2+ regulation of striated muscle contraction. When Ca2+ is released from sarcoplasmic reticulum and bound to Tn, the complex undergoes a conformational change that moves Tm away from myosin binding sites on actin, sites that are blocked in the absence of Ca2+. This allows actomyosin cross-bridge cycling, resulting in force generation and/or sarcomere shortening.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
