Mechanical, Electrical, and Biological Properties of Mechanochemically Processed Hydroxyapatite Ceramics.

Sujata Swain,Sonia Sharma,Anuj Kumar,Sudip Dasgupta,Pawan Kumar,Mukesh Kumar Gupta,Rakesh Bhaskar

doi:10.3390/nano11092216

Sujata Swain, Sonia Sharma + Show 5 more

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https://doi.org/10.3390/nano11092216

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Abstract

The effect of the sintering temperature on densification and the resultant mechanical, electrical, and biological properties of mechanochemically processed hydroxyapatite (HAp) samples was investigated. HAp samples were sintered at 1200, 1250, and 1300 °C for 4 h, respectively. HAp samples sintered at 1250 °C showed better mechanical properties, which was attributed to their smaller grain size compared to HAp samples at higher sintering temperatures. The nearly identical value of the dielectric constant (εr) and better cell proliferation was exhibited by HAp samples sintered at 1250 and 1300 °C, respectively. At ~210 °C, in all the samples sintered at different temperatures, a dielectric anomaly was obtained, which was attributed to the phase transition temperature of the HAp system. Dielectric properties near the phase transition temperature showed a dielectric relaxation-type of behavior, which was attributed to the re-orientational motion of OH− ions in the HAp system. Higher cell proliferation and viability were exhibited by the HAp1300 samples, whereas comparatively equivalent cell growth and higher mechanical strength were observed in the HAp1250 samples.

Highlights

IntroductionHAp, a calcium phosphate-based bioceramic, is an extensively used biomaterial for bone substitution [1]
HAp samples were successfully synthesized by an high-energy ball-milling (HEBM)-assisted solid-state reaction route
The presence of a small amount of the β-tricalcium phosphate (β-TCP) phase was observed in all the HAp samples, sintered at different temperatures

Summary

Introduction

HAp, a calcium phosphate-based bioceramic, is an extensively used biomaterial for bone substitution [1]. This is because the HAp system has a similar chemical composition as that of human bones, excellent biocompatibility, and good osteoconductive properties, which make it one of the important implant materials for orthopedic-related treatments [2,3]. The HAp system shows excellent stability in an aqueous medium above pH 4.3, which is within the range of the pH of human blood [4]. Several studies have shown that, for load-bearing applications, a dense form of HAp ceramic is required [5]. The well-defined particle morphology of HAp powder makes it quite effective in biomedical applications [4]

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