Abstract
A selected history of mechanical circulatory support the physiology of left ventricular assistance the biomaterial - blood interface in circulatory support devices - a cardiac surgeon's view the development of biomaterials for cardiovascular prostheses. Part 1 Advanced respiratory support: the need for advanced respiratory support in the intensive care unit technical overview of advanced respiratory support the IVOX intravascular gas-exchange device - current world-wide experience extracorporeal membrane oxygenation for neonates and older children adult ECMO. Part 2 Cardiopulmonary bypass: pulsatile and non-pulsatile perfusion in cardiac surgery - the continuing controversy the choice of blood pump for cardiopulmonary bypass. Part 3 Short-term support: principles of intra-aortic balloon counterpulsation the development of future of the Hemopump clinical uses of the Hemopump development, indications and clinical use of centrifugal blood pumps mechanical circulatory support - patient and device selection. Part 4 Medium-term support: the Thoratec VAD system - patient selection and clinical results in bridge to transplantation. Part 5 Long-term support: the need for long-term circulatory support - a cardiologist's view end-organ function with long-term support development and clinical use of the total artificial heart - a review of the current status of the CardioWest C-70 TAH (Jarvik-7) clinical use of a total artificial heart - overall European experience the future of TAH worldwide clinical experience of the Novacor device worldwide clinical experience of TCI device the Novacor left ventricular assist system TCI Heartmate blood pump. Part 6 Biological assist: transplantation xenotransplantation - current status and future prospects educating skeletal muscle to do cardiac work circulatory assistance with skeletal muscle ventricles clinical use of skeletal muscle counterpulsation the experimental evidence for skeletal muscle support in cardiomyoplasty clinical uses of myoplastic techniques. Part 7 Problems: valves in pulsatile devices bleeding complications in patients requiring mechanical circulatory support management of bleeding in ECMO anticoagulants and the artificial heart linings cannulation techniques in cardiac support systems cannulation for ECMO infectious complications associated with ventricular assist device support optimizing flow in centrifugal blood pumps use of aprotinin in mechanical circulatory support. Part 8 General issues: regulatory and informed consent issues in circulatory support economic evaluation of therapies for end-stage heart failure ethical considerations for circulatory support the bridge to transplantation. Appendix: device registry.
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