Mechanical characterization of bone quality in distal femur fractures using pre-operative computed tomography scans

Abstract

BackgroundMechanical testing of implant constructs designed to treat distal femur fractures has been hampered by a lack of clinical data on the biomechanical properties of the distal femur in patients who sustain these fractures. Therefore, the purpose of this study was to use quantitative computed tomography (qCT) to investigate the mechanical characteristics of fractured distal femurs to inform the selection of synthetic materials for biomechanical testing. MethodsDistal femur fractures treated at a Level I trauma center were retrospectively reviewed and 43 cases with preoperative CT scans were identified for analysis. Scans were segmented and each bone fragment was reconstructed as a 3D model. The Young's modulus of the distal femur was determined from voxel-based radiodensity. FindingsMedian patient age was 72 years (IQR = 57–81), with 26% males and 74% females. Young's modulus in the distal femur was negatively correlated with patient age (R2 = 0.50, p < 0.001). The distribution of patient-specific modulus values was also compared with the compressive modulus ranges for graded polyurethane foams according to ASTM F1839. Bone quality ranged from Grade 25 in younger individuals to Grade 5 in older individuals. ConclusionNo single grade of synthetic polyurethane foam can be selected to model all clinically important scenarios for biomechanical testing of distal femur fracture fixation devices. Rather, this data can be used to select an appropriate material for a given clinical scenario. A Grade 25 foam is appropriate for implant longevity, whereas for implant stability, Grades 5-15 are more appropriate.