Abstract
In this work, we study the mechanical properties of abdominal aortic aneurysms (AAAs) treated by cell therapy. Based on the xenograft model in rats, we analyze the effects of the injection of bone marrow mesenchymal stem cells (MSCs) on the stiffness of the arterial wall. Uniaxial tests performed on control, treated and untreated samples, have led to the identification of a nonlinear behavior law, using a mechanical model based on a stress-stretch exponential relation. The comparison of the mechanical behavior shows the benefits of the proposed cell therapy which improves the mechanical strength of the aneurysmal vessel wall. A histological study has shown the favorable change expression of elastin and collagen which are involved in the mechanical behavior of repaired arterial tissue. Thus, this work is part of MSCs biological understanding and it contributes to evaluate the approaches used in cell therapy and regenerative medicine to treat AAAs.
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