Abstract
In the in vitro fertilization (IVF) clinic, several oocytes are collected from a patient and assessed for maturation. Oocytes which have visibly completed nuclear maturation (MII stage) and extruded a polar body are deemed mature and ready for fertilization. Those which lack a polar body (GV or MI stage) then undergo in vitro maturation (IVM) until they reach the MII stage and are ready for fertilization. Although nuclear maturation is easy to assess by simple observation, oocytes must also undergo cytoplasmic maturation before acquiring optimal developmental competence.
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