Abstract
Progesterone responsive genes are implicated in fibroid growth, but the mechanisms that integrate mechanical signaling with progesterone receptor activation are not fully understood. We previously reported that a mechanically stiff substrate promoted progesterone-dependent, progesterone receptor-mediated gene activation in fibroid cells. Here we investigated whether altered mechanical stiffnesses directly influenced phosphorylation of progesterone receptor B (PRB), and used siRNA directed against PRB to test whether this isoform was required to transduce mechanical signals in fibroid cells.
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