Mechanical and metabolic performance of the rat heart: effects of combined stress of heat acclimation and swimming training.

Abstract

Although the individual effects of heat acclimation and swimming exercise on cardiovascular reserve and efficiency have been studied, the relative and cumulative effects of these interventions have not. Myocardial developed force, coronary flow (CF), and oxygen consumption during baseline conditions and during pacing-induced tachycardia were therefore studied in isolated perfused hearts from four groups of rats: normothermic sedentary (C), heat acclimated sedentary (AC), normothermic swimmers (CS), and heat acclimated swimmers (ACS). Normothermic temperature was 24 degrees C. Heat acclimation was attained by continuous exposure to 34 degrees C for one and two months. Swimmers had two daily 75 minute sessions for five days a week with water temperatures of 33-35 degrees C and 36-38 degrees C for CS and ACS rats, respectively. After one month AC animals showed a remarkable decrease in O2 consumption. In contrast, ACS increased both O2 consumption and the maximal isometric force generated. After two months, O2 consumption of AC rats continued to be low. The heart failed to restitute the force developed at high pacing frequency. In these rats CF was remarkably low and remained unchanged with increased pacing. In contrast ACS maintained the ability to develop force at all pacing rates at a level similar to that of the normothermic C and ACS rat hearts, but at high oxygen cost. The data suggest that the AC heart is more efficient but cannot meet demands at high pacing rates. In contrast, swimming in the heat improved performance of ACS temporarily, without decreasing the metabolic rate.