Abstract
To review the clinical and biochemical changes in neurotransmission and antioxidant system in phenylketonuric patients under dietary treatment. Phenylketonuria (PKU) is an inborn error of metabolism caused by decreased activity of the enzyme L-phenylalanine-4-mono-oxigenase that synthesizes tyrosine from phenylalanine. According to analytical data from PKU patients and to experimental studies in animal models, high phenylalanine values in plasma and tissues seem to be related with defective biosynthesis of neurotransmitter (mainly serotonin and dopamine) and impairment of antioxidant system. Despite dietary treatment, PKU patients usually present moderate hyperphenylalaninemia over the evolution of the disease that might cause clinical and biochemical abnormalities. Increased plasma phenylalanine concentrations and dietary treatment might be related with neurotransmitter and antioxidant system abnormalities in human phenylketonuria. These biochemical alterations might be involved in the physiopathology of PKU.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
