Abstract
Objetivo: compreender a ação do EGF no comportamento periimplantar e quais as conseqüências dessa interação com as mudanças ocorridas nos componentes protéticos das próteses implantossuportadas. Material e Métodos: foi realizada uma busca nos indexadores do banco de dados OldMedline e Medline, entre 1980 e 2017, com os seguintes termos em inglês: fator de crescimento epidérmico, osseointegração e reabsorção óssea. Para a literatura nacional, foi utilizado o indexador BBO. Da mesma forma, os termos fator de crescimento epidérmico, osseointegração e reabsorção óssea foram investigados, no mesmo período. Resultados: recentemente, em termos de ciência, verificou-se que os EGFs têm um papel na manutenção de distâncias biológicas também nos tecidos peri-implantares. A reabsorção do osso cervical, conhecida como cauterização, que causa a diminuição do nível da crista alveolar é causada pela abordagem do epitélio escamoso estratificado da mucosa bucal, após o ato cirúrgico, ao osso subjacente. Conclusão: o mediador EGF interage com os receptores que formam o epitélio juncional peri-implantar, cuja conformação aproxima o osso, acelerando a reabsorção e provocando a cauterização. Mudanças nos componentes protéticos têm sido constantes para se adequar ao comportamento periimplantar.
Highlights
Epidermal growth factor or epidermal or epithelial growth factor (EGF) is a mediator, it has the primary function of stimulating growth, differentiation and proliferation of epithelial cells
This work aims to review the literature on the action of EGFs on peri-implant behavior and the substantially alteration on the prosthetic components used in contemporary osseointegrated implants
Other types of correlation or assumption not directly cited between re-absorption around peri-implant bone tissue were excluded, as well as changes in the biological distances promoted by periodontal diseases, occlusion forces and their resulting, lack of reverse planning, many syndromes, bone alterations promoted by medications or deleterious habits, lack of careful execution in the prosthetic phase before the placement of the fixations or theories discordant of the direct action of the EGFs and the saucerization
Summary
Epidermal growth factor or epidermal or epithelial growth factor (EGF) is a mediator, it has the primary function of stimulating growth, differentiation and proliferation of epithelial cells It is present in human (100 μm / mL), maternal (80 μm / mL), salivary (12 μm / mL), plasma fluid (100 μm / mL) and amniotic fluid (1 μm / mL). The junctional epithelium is induced to proliferate, produces EGF, and continuous proximity to the alveolar bone crest induces a bone resorption, lowering it in the cervico-apical direction.[5] The term saucerization is well knowing by the literature in implantology. The approach of the peri-implant bone-integrated in the apical surface of the junction epithelium is responsible for increasing the regional concentration of EGF; and the resorption of the alveolar bone crest in contact with the implant, that is, the saucerization.[1]. This work aims to review the literature on the action of EGFs on peri-implant behavior and the substantially alteration on the prosthetic components used in contemporary osseointegrated implants
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