Abstract
PurposeTo measure progression of the visual field (VF) mean deviation (MD) index in longitudinal 10-2 VFs more accurately, by adding information from 24-2 VFs using Lasso regression.MethodsA training dataset consisted of 138 eyes from 97 patients with glaucoma or ocular hypertension and a testing dataset consisted of 40 eyes from 34 patients with glaucoma or ocular hypertension. The Lasso method was used to predict total deviation (TD) values in training patients’ 10-2 VFs based on information from their 24-2 VFs (52 TD values, foveal sensitivity and mean deviation MD). Then, the MD of each patient’s 10-2 VF was estimated as the average of these Lasso-predicted TD values (10-2 VF ‘Lasso MD’; LMD). Finally, linear regression was applied to each testing patient’s series of longitudinal 10-2 VF MDs with and without additional Lasso-derived LMDs in order to predict future MDs not included in the regression analysis. Absolute prediction errors were compared when only actual 10-2 MDs were regressed against when a combination of actual 10-2 MDs and LMDs were regressed.ResultsThe average absolute prediction error was significantly smaller for the novel method incorporating LMDs (range: 1.6 to 1.8 dB) compared with the standard approach (range: 1.7 to 3.4 dB) (p<0.05, ANOVA test).ConclusionsDeriving 10-2 VF MD values from 24-2 VFs improves the prediction accuracy of progression. This approach will help clinicians to predict patients’ visual function in the parafoveal area.
Highlights
Glaucoma is one of the leading causes of blindness in the world [1,2]
Glaucomatous visual field (VF) change usually manifests in the mid-peripheral VF, while the central region tends to retain visual function until late on in the disease process
VF damage is often characterized by large arcuate scotomata in the upper and lower hemifields, which have connected to form a ring, threatening visual function in the central area of the VF [3,4]
Summary
Glaucoma is one of the leading causes of blindness in the world [1,2]. Glaucomatous visual field (VF) change usually manifests in the mid-peripheral VF, while the central region tends to retain visual function until late on in the disease process. VF damage is often characterized by large arcuate scotomata in the upper and lower hemifields, which have connected to form a ring, threatening visual function in the central area of the VF [3,4]. Paracentral VF defects are especially important because VF damage in this area leads to disability in various daily tasks [5], and increases the risk of falls, hip fractures and mortality [6,7]. Treatments should be intensified when the rate of VF damage threatens the patient’s visual function, in the central region. In consequence, predicting glaucomatous VF progression in the central area is one of the most important tasks faced by a clinician. Measuring 10u VF progression is difficult since test patterns are not consistent, and the number of 10u VF is often small
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