Abstract
A versatile setup based on a microfluidic platform allows investigation of liquid samples at various temperatures with terahertz time-domain spectroscopy. The setup is applied to develop a novel method that performs temperature and concentration calibrations of liquid samples at terahertz frequencies. Other than measuring the concentration of pure liquid phase solutions, it enables the studies of local concentration of semicrystalline systems. An equivalent solute concentration during crystallization can be calculated from the extracted absorption at low frequencies. The MgSO4-water system is discussed as an example to illustrate the idea of this method.
Highlights
Terahertz time-domain spectroscopy (THz-TDS) is a useful far-infrared spectroscopy tool that is increasingly used in the field of solid state crystallography to complement x-ray diffraction methods to distinguish between polymorphs and other solid forms, as it probes collaborative motions in molecular systems that are largely influenced by the different crystalline packing.[1]
Its use can be extended to study crystallisation itself and it has been shown that even low amounts of crystallinity can be detected in semi-crystalline systems,[2] and we recently developed a setup that allows for the in-situ investigation of crystallisation from the liquid phase over a range of concentrations and temperatures.[3]
Reference terahertz spectra of crystalline MgSO4·7H2O in the solid state were acquired over a range of temperatures in order to characterise the vibrational features that are characteristic of the crystalline form
Summary
Terahertz time-domain spectroscopy (THz-TDS) is a useful far-infrared spectroscopy tool that is increasingly used in the field of solid state crystallography to complement x-ray diffraction methods to distinguish between polymorphs and other solid forms, as it probes collaborative motions in molecular systems that are largely influenced by the different crystalline packing.[1]. Reference terahertz spectra of crystalline MgSO4·7H2O in the solid state were acquired over a range of temperatures in order to characterise the vibrational features that are characteristic of the crystalline form.
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