Measuring of cardiac electrical system function among salbutamol inhaled children – A cohort study

Abstract

Background: Salbutamol is widely recognized as an effective rescue therapy for acute asthma attacks. However, the usage of inhaled β2-agonists, including salbutamol, has been related to an amplified hazard of cardiovascular disease, as suggested by several studies. Despite this association, there is an absence of sufficient facts regarding the cardiac electrophysiological possessions of inhaled β2-agonists in children. Aim and Objectives: The present study was to explore the cardiac electrophysiological effects of inhaled salbutamol in children. By examining the specific impact of salbutamol on cardiac electrophysiology, this study aimed to contribute valuable insights into the potential cardiovascular effects of inhaled β2-agonists in the pediatric population. Materials and Methods: This cohort study involved 130 individuals of both sexes, levels in age from 1 to 12 years. Salbutamol nebulization was administered to the children at a dosage of 0.15 mg/kg/dose, mixed with normal saline at a ratio of 1:3, using a nebulizer. Cardiac parameters including heart rate, T axis, P axis, QTc interval, QRS axis, QRS interval, and PR interval were recorded before and after nebulization using a computerized electrocardiogram (ECG). Results: The outcomes of the work presented that following nebulization, there was a major rise in heart rate and a notable decline in the PR interval, T axis, and P axis. However, no analytical significant deviations were observed in the QRS axis, QTc interval, and QRS interval. Conclusion: The study demonstrates that within a time frame of 5–15 min after inhaling a single standard dose of salbutamol, significant changes in the ECG parameters occur. These changes in cardiac electrophysiology may contribute to an amplified occurrence of arrhythmias in some patients getting salbutamol treatment. It is important to note that the frequent use of high doses of salbutamol for asthmatic exacerbations may potentially lead to more severe cardiac adverse effects.