Measuring Exercise-Induced Secreted Protein Acidic and Rich in Cysteine Expression as a Molecular Tool to Optimize Personalized Medicine.

Abdelaziz Ghanemi,Mayumi Yoshioka,Jonny St-Amand

doi:10.3390/genes12111832

Abdelaziz Ghanemi, Mayumi Yoshioka + Show 1 more

Open Access

https://doi.org/10.3390/genes12111832

Copy DOI

Journal: Genes	Publication Date: Nov 20, 2021
Citations: 11	License type: CC BY 4.0

Affiliation: Université Laval

Abstract

The numerous exercise benefits for health as well as applications for diseases has lead to exercise being prescribed in many pathological conditions. Secreted protein acidic and rich in cysteine (SPARC) gene expression is stimulated by exercise and SPARC has been suggested as a molecular mediator of exercise. Therefore, we suggest using this property for personalized medicine. This can be achieved by prescribing the exercise with a pattern (duration, intensity, etc.) that corresponds to the optimum SPARC/Sparc expression. We expect this approach to optimize the exercise therapy in both the preventive and curative contexts. In the research field, measuring exercise -dependent expression of Sparc would represent a molecular tool to further optimize the selection of exercise animal models as well.

Highlights

The numerous exercise benefits for health as well as applications for diseases has lead to exercise being prescribed in many pathological conditions
Regarding the molecular mechanism linking exercise and the exercise-induced effects, exercise benefits have been suggested to be mediated through a variety of factors, mainly the muscle-secreted myokines [26] that are produced by skeletal muscles and increase in response to exercise [27]
Such an exercise-induced pattern of secretion suggests that these myokines would govern the molecular pathways underlying the phenotypic changes resulting from exercise in different organs and tissues leading to the known health benefits of the physical activity

Summary

Introduction

The numerous exercise benefits for health as well as applications for diseases has lead to exercise being prescribed in many pathological conditions. Such an exercise-induced pattern of secretion suggests that these myokines would govern the molecular pathways underlying the phenotypic changes resulting from exercise in different organs and tissues leading to the known health benefits of the physical activity.

Results

Conclusion