Abstract
Since 1986, ultrasound-based measurement of the carotid artery wall intima-media complex has evolved from a simple pathologic observation to a tool for evaluating responses to cholesterol-lowering therapies and a clinical adjunct for cardiovascular risk assessment. Many variations of protocols for the measurement of carotid artery intima-media thickness (IMT) now exist, from simple protocols that measure only the common carotid artery on one side of the neck to complex ones with a full bilateral study that includes 30 images. It is possible that complex IMT measurement protocols might improve the likelihood of detecting differences between treatment and nontreatment arms of cholesterol-lowering intervention trials. However, there are no firm data to support this view, as shown in the next section. The evidence for complex IMTmeasurement protocols is reviewed in the section that follows.
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