Abstract

The effects of temperature, relative humidity and molecular structure on the crystallization process within amorphous solids have been explored. Lactose and sucrose were spray dried, and the products were exposed to different and relative humidities. To investigate the effect of temperature, experiments were conducted at both room temperature and 40oC. The rate of the crystallization was more than doubled for every increase of temperature by 10oC, up to three times for the case of lactose. These results are consistent with the picture of the process as an activated rate one. The effect of increasing relative humidity (RH) was observed to increase the rate of crystallization up to a threshold value, after which the rate was no longer affected by relative humidity. This threshold was found to be 51% for sucrose, at room temperature, which was lowered to 32% at 40oC. Lactose and sucrose, which have the same molecular weight of 342 g/mol but different molecular structures and thus glass transition temperatures, were exposed to similar conditions. The difference in molecular structures had little effect on the overall rate of the crystallization process for the same material temperatures, in contrast with the predictions of the Williams Landel Ferry equation, which suggests that the rate of crystallization is a function of the difference between the material temperature and the glass transition temperature.

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