Abstract
We present the optical measurement techniques used in human skin phantom studies. Their accuracy and the sources of errors in microscopic parameters’ estimation of the produced phantoms are described. We have produced optical phantoms for the purpose of simulating human skin tissue at the wavelength of 930 nm. Optical coherence tomography was used to measure the thickness and surface roughness and to detect the internal inhomogeneities. A more detailed study of phantom surface roughness was carried out with the optical profilometer. Reflectance, transmittance, and collimated transmittance of phantoms were measured using an integrating-sphere spectrometer setup. The scattering and absorption coefficients were calculated with the inverse adding-doubling method. The reduced scattering coefficient at 930 nm was found to be 1.57±0.14 mm(−1) and the absorption was 0.22±0.03 mm(−1) . The retrieved optical properties of phantoms are in agreement with the data found in the literature for real human tissues.
Highlights
The emergence of new optical measurement techniques in the field of biophotonics has increased the interest in the possibility of their use for medically relevant, noninvasive in vivo imaging and measurements.[1,2,3,4,5,6,7,8,9,10] The development and evaluation of such methods require frequent calibration of the devices
We have presented a number of optical techniques used to characterize properties of developed tissue phantoms designed for simulating optical properties of human skin at around 930 nm
The surface profile of the phantoms was determined with an accuracy
Summary
The emergence of new optical measurement techniques in the field of biophotonics has increased the interest in the possibility of their use for medically relevant, noninvasive in vivo imaging and measurements.[1,2,3,4,5,6,7,8,9,10] The development and evaluation of such methods require frequent calibration of the devices. The scattering, absorption, and scattering anisotropy are the fundamental microscopic properties that describe the photon migration in a turbid medium, such as tissues;[27,28] the design and production processes of tissue phantoms focus on their exact matching. These microscopic properties can be measured indirectly by measuring macroscopic parameters, such as reflectance or transmittance, and by applying a model of light propagation.[29] The inverse adding-doubling (IAD) method can be used to calculate the coefficients of the sample from. Measured parameters include the optical properties, geometry, and surface roughness
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