Abstract
The magnitude of dendritic conductance changes occurring distantly from the somatic site of recording can be difficult to measure. We have used measurements of the neuronal time constant, τ 0, instead of the neuronal input resistance, R N, to estimate the resistance decrease that accompanies the depolarizing response of the dendrites of granule cells when GABA is applied. From the changes in τ 0, we estimated the reversal potential of the response and found that the conductance change accompanying a given GABA-mediated voltage response as measured at the cell body was the same regardless of where in the dendritic tree the drug was applied. On the other hand, R N changes underestimated the increase in conductance of the GABA responses in the distal dendrites and were not accurate for determining the reversal potential.
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