Abstract
Abstract Concentrations of immunoglobulins in human serum are frequently measured for both clinical and research purposes, and the values have been expressed in terms such as milligrams/milliliter. However, there has been little confidence that concentrations, as estimated by different laboratories using different reference materials, are comparable. With the object of improving the uniformity of estimates by different laboratories, a freeze-dried preparation of human serum, coded 67/86, has been assessed for use as a standard for measurements of human serum immunoglobulins IgG, IgA and IgM by techniques of immunodiffusion (1). Part of this batch of material has been established by the World Health Organization1 as the International Reference Preparation of Human Immunoglobulins IgG, IgA and IgM, and international units have been assigned to it such that each ampule of the International Reference Preparation contains on average 100 IU of IgG, 100 IU of IgA and 100 IU of IgM.
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