Abstract
Objective: To develop an optimal follow-up treatment for neonatal and nosocomial infections and to examine correlations between the C-reactive protein (C-RP) and platelets. Methods: A sample of 27 septic neonates and 14 non-septic neonates were selected for this study. The non-septic neonates served as a control group. Blood samples were collected from both groups and analyzed for bacterial contamination via blood culture, complete blood count (CBC), and C-RP, according to international laboratory standards. Blood collection and analysis were repeated every day during the follow-up treatments with antibiotics to evaluate the kinetics of C-RP. Results: Blood culture found E. coli and Staphylococcus aureus in the blood of the septic cases. Serum C-RP concentrations were at high levels (24 mg/dl) in the septic neonates and at normal levels (lower than 6 mg/dl) in the control group. Treatment with active antibiotics resulted in a drastic reduction of the C-RP values and helped to reach a normal level as in the control group. On the other hand, there were increases in the platelet levels as the C-RP levels decreased. This result indicates a strong negative association between C-RP and platelet levels in the septic group only. Statistical analysis shows significant differences between the mean C-RP serum concentrations of the sepsis and non-sepsis. Conclusion: blood culture, active antibiotics, and kinetic C-RP measurements during the medical follow-up treatment are strong driving parameters for the optimal and successful management of sepsis.
Highlights
Blood samples were collected from both groups and analyzed for bacterial contamination via blood culture, complete blood count (CBC), and C-reactive protein (C-RP), according to international laboratory standards
Treatment with active antibiotics resulted in a drastic reduction of the C-RP values and helped to reach a normal level as in the control group
Microbe antibiotic sensitivity tests showed that E. coli is sensitive to Amikacin, Ciprofloxacin and Gentamicin; Klebsiella is sensitive to Amikacin, Meropenem and Vancomycin; and Staphylococcus aureus is sensitive to Amikacin, Ciprofloxacin, Meropenem and Cefotaxime
Summary
The population of the sample size was calculated using Google sample size calculator (http://www.raosoft.com/samplesize.html 2018) in which the sample size are 41 septic neonates. All cases were recorded during seven months of the study period. The septic cases were 14 nosocomial and 13 neonatal sepsis, in total 27 cases. The parents of the sepsis and non-sepsis cases were interviewed for data collection. Tion with or without accompanying bacteremia in the first 72 hours of age. It encompasses various systemic infections of the newborn such as septicemia, meningitis, pneumonia, arthritis, osteomyelitis, and urinary tract infections. Case of nosocomial (hospital-acquired) or community-acquired and neonates usually present with septicemia, pneumonia or meningitis after 72 hours of age up to 28 days
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