Abstract
We have measured serum osteocalcin ∗∗ ∗∗ Osteocalcin has also been referred to as ‘bone Gla protein’ (BGP) in the literature [5]. by radioimmunoassay, and urinary γ-carboxyglutamic acid (Gla) by Dowex-1 chromatography in healthy adults and children. Circulating osteocalcin is6.8 ± 0.5 and 5.8 ± 0.5 ng/ml in adult males ( n = 25) and females ( n = 26), respectively. Values are higher in children ( n = 26), ranging from 25–30 ng/ml in a 1-year-old and declining to the adult level at puberty. The ratio of urinary Gla/creatinine as a function of age parallels the pattern of serum osteocalcin. Free Gla ranges from a high of 150 ± 20 μmol Gla/g creatinine in infants ( n = 17), decreasing until puberty at which time the excretion stabilizes at 44 ± 4 μimol Gla/g creatinine ( n = 27). The greater amounts of circulating steocalcin and urinary Gla most likely reflect synthesis of osteocalcin during growth. With epiphyseal closure, levels decline and, in the adult, probably represent normal bone remodelling.
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