Measurement Serum Levels of IFNY, IL-17 and IL-4 of Psoriasis patients in Al- Najaf City

Abstract

Background: Psoriasis is an inflammatory skin disorder characterized by activation of lymphocytes, systemic and local over expression of pro-inflammatory cytokines. Objectives: The study was designed to investigate the level of cytokines in patients with psoriasis and study the correlation of the cytokines with disease severity. Methodology: Blood samples were collected of seventy patients with psoriasis for measurement of (IFNγ, IL-17 and IL-4) by ELISA technique. Results: High levels of IFNγ and IL-17 were observed in patients with psoriasis. It was found that the mean levels of IFNγ and IL-17 were significantly correlated to disease severity. Moreover, the mean level of IL-4 in psoriatic patient was found to decrease significantly according to graded severity of the disease. Statistical analysis was done by using SPSS (statistical package for social sciences) in which T-test and ANOVA test were used and chi- square (X2) test for categorical data. Conclusion: The study concluded that the level of IFNγ and IL-17 may play a key role as an indicator in the immunopathogenesis of psoriasis and markers of disease activity. Recommendation: Using another cytokines and study effect of these cytokines with disease severity.