Measurement of the Orbital Soft Tissue Volume in Chinese Adults Based on Three-Dimensional CT Reconstruction.

Yi Du,Bing-Yao Lu,Jian-Feng He,Jun Chen

doi:10.1155/2019/9721085

Yi Du, Bing-Yao Lu + Show 2 more

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https://doi.org/10.1155/2019/9721085

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Abstract

Quantitative measurement of the orbital soft tissue volume plays a very important role in the study of orbital diseases. The purpose of this study is to establish a computed tomography- (CT-) based three-dimensional (3D) reconstruction model and measure the orbital soft tissue volume in Chinese adults. We collected data from 103 Chinese adults (52 males and 51 females) who underwent orbital CT. The CT images of these adults were used to reconstruct a 3D model of the orbital bony cavity, orbital fat, extraocular muscle, and intraorbital optic nerve using Mimics software, and their respective volumes were measured. The mean (±SD) orbital bony cavity volume (OV), orbital fat volume (FV), extraocular muscle volume (MV), and intraorbital optic nerve volume (iONV) of the males were 22.2 ± 2.2 cm3, 8.9 ± 1.8 cm3, 1.9 ± 0.34 cm3, and 0.41 ± 0.08 cm3, respectively. The mean OV, FV, MV, and iONV of the females were 20.2 ± 1.5 cm3, 8.1 ± 1.7 cm3, 1.6 ± 0.3 cm3, and 0.36 ± 0.074 cm3, respectively, which were all significantly lower than those in males (all p < 0.05). FV (r = 0.370; p < 0.001) and MV (r = 0.283; p=0.007) were significantly correlated with body mass index (BMI), while iONV was not correlated with BMI (r = −0.070; p=0.480). This study shows that FV, MV, and iONV were higher in males than in females. With increasing BMI, FV and MV both increased, but iONV did not exhibit this trend.

Highlights

Many ocular diseases can cause volume changes in orbital soft tissues; e.g., thyroid-associated ophthalmopathy can lead to extraocular muscle thickening and increased orbital fat [1], while optic neuritis can cause optic nerve thickening [2]. erefore, quantitative measurement of the orbital soft tissue volume plays a very important role in the study of orbital diseases
Based on computed tomography (CT) or magnetic resonance imaging (MRI), the region of interest can be delineated and transformed into a 3D reconstruction model to calculate the volume of the study object using computer software [3,4,5]. is method is noninvasive, intuitive, and accurate and a highly feasible method to quantitatively measure tissue volume
There are differences in eye parameters between Asians and Caucasians [3,4,5, 8]. ese differences are very unfavorable to study orbital soft tissue diseases in Asian patients with volume changes. is study intended to establish a 3D model of the orbital bony cavity and orbital soft tissues based on CT tomography images and calculate their volumes by computer software

Summary

Introduction

Many ocular diseases can cause volume changes in orbital soft tissues; e.g., thyroid-associated ophthalmopathy can lead to extraocular muscle thickening and increased orbital fat [1], while optic neuritis can cause optic nerve thickening [2]. erefore, quantitative measurement of the orbital soft tissue volume plays a very important role in the study of orbital diseases.Presently, the two-dimensional digital tomographic image sequence can be processed by using computers for transformation into a three-dimensional (3D) geometric model with an intuitive three-dimensional effect. Many ocular diseases can cause volume changes in orbital soft tissues; e.g., thyroid-associated ophthalmopathy can lead to extraocular muscle thickening and increased orbital fat [1], while optic neuritis can cause optic nerve thickening [2]. Erefore, quantitative measurement of the orbital soft tissue volume plays a very important role in the study of orbital diseases. Based on computed tomography (CT) or magnetic resonance imaging (MRI), the region of interest can be delineated and transformed into a 3D reconstruction model to calculate the volume of the study object using computer software [3,4,5]. Ese differences are very unfavorable to study orbital soft tissue diseases in Asian patients with volume changes. Is study intended to establish a 3D model of the orbital bony cavity and orbital soft tissues based on CT tomography images and calculate their volumes by computer software. We analyzed the relationship between the orbital soft tissue volumes and physical indicators such as sex, age, height, body weight, and body mass index (BMI). e purpose of this study was to obtain a reference range for the orbital soft tissue volume in Chinese adults

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